Erik Mosekilde · Biosimulation in Biomedical Research, Health Care

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Amin is a Professor of Systems Pharmacology at the Centre for Applied  Professor Rostami is the Senior Vice President of Research & Development and Chief Scientific Officer at Certara. His mission is to ensure that the latest  Amin Rostami-Hodjegan, The University of Manchester, United Kingdom Amin is currently the Director of the Centre for Applied Pharmacokinetic Research  12 Oct 2017 Amin Rostami‐Hodjegan indicated the possibility of reduced enzyme activity in renal impairment patients (Rostami‐Hodjegan et al.12). Alice Ban Ke,1 Amin Rostami-Hodjegan,2,3 Ping Zhao,4 and Jashvant D. Unadkat5. 1Drug Disposition, Lilly Research Laboratories, Indianapolis, Indiana   Erik Mosekilde; Olga Sosnovtseva; Amin Rostami-Hodjegan.

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We are at the forefront of the search for solutions to some of the world's most pressing problems, seeking to be a global force for positive change. Thomas M. Polasek, Carl M. J. Kirkpatrick, and Amin Rostami-Hodjegan. Therapeutic Advances in Drug Safety 2019 10.1177/2042098619894147 Download Citation. Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in which the characteristics of each patient are considered as opposed to applying a one-size-fits-all alternative. This review provides a brief account of the current knowledge, pra … In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and degradation. A current lack of consensus on values of the in vivo turnover half-lives of human cytochrome P450 (CYP) enzymes places a significant limitation on the accurate prediction of changes in drug concentration-tim … Amin Rostami-Hodjegan is Chief Scientific Officer at Certara USA, Inc. View Amin Rostami-Hodjegan’s professional profile on Relationship Science, the database of decision makers.

Start - Department of Pharmacy - Uppsala University, Sweden

Häftad, 2014. Skickas inom 10-15 vardagar. Köp Biosimulation in Biomedical Research, Health Care and Drug Development av Erik Mosekilde, Olga Sosnovtseva, Amin Rostami … 2016-03-29 Amin Rostami‐Hodjegan. University of Sheffield, Section of Molecular Pharmacology and Pharmacogenetics, Division of Clinical Sciences, The Royal Hallamshire Hospital, Sheffield, Search for more papers by this author.

Biosimulation in Biomedical Research, Health Care and Drug

Review.

Adam S. Darwich, Kathryn Henderson, Angela Burgin, Nicola Ward, Janet Whittam, Basil J. Ammori, Darren M. Ashcroft & Amin Rostami-Hodjegan Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects Amin Rostami-Hodjegan, The University of Manchester, United Kingdom Amin is currently the Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester. He was the first full Professor appointed with the title of Systems Pharmacology. Professor Rostami in 2007 at the University of Sheffield. 演者： Amin Rostami-Hodjegan （Centre for Applied Pharmacokinetic Research, University of Manchester, UK ／Certara, Princeton, New Jersey, USA.） シンポジウム5（代謝・毒性 DIS 2） 2019年12月11日（水）9：30〜11：45 C会場（2F 中会議室201） Hajar Al Feteisi, Brahim Achour, Amin Rostami-Hodjegan, Jill Barber, Translational value of liquid chromatography coupled with tandem mass spectrometry-based quantitative proteomics for in vitro – in vivo extrapolation of drug metabolism and transport and considerations in selecting appropriate techniques , Expert Opinion on Drug Metabolism & Toxicology, 10.1517/17425255.2015.1055245, 11, 9 Jill Barber, Matthew R. Russell, Amin Rostami-Hodjegan, Brahim Achour. Characterization of CYP2B6 K262R allelic variants by quantitative allele-specific proteomics using a QconCAT standard. Journal of Pharmaceutical and Biomedical Analysis 2020, 178 , 112901.
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2019-12-11 amin.rostami@manchester.ac.uk; Centre for Applied Pharmacokinetic Research (CAPKR), University of Manchester, UK, and Certara, Princeton, New Jersey, USA. Correspondence: Amin Rostami‐Hodjegan (amin.rostami@manchester.ac.uk)Search for more papers by this author Amin Rostami‐Hodjegan, PhD, PharmD, FCP, Stopford Building, Oxford Road, Manchester, United Kingdom of Great Britain and Northern Ireland, M13 9PT UK. Email: amin.rostami@manchester.ac.uk. Search for more papers by this author 2021-04-01 2007-02-01 Amin Rostami-Hodjegan is the author of ADME (0.0 avg rating, 0 ratings, 0 reviews, published 2009) and Biosimulation in Biomedical Research, Health Care In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and degradation. A current lack of consensus on values of the in vivo turnover half-lives of human cytochrome P450 (CYP) enzymes places a significant limitation on the accurate prediction of changes in drug concentration-tim … Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in which the characteristics of each patient are considered as opposed to applying a one-size-fits-all alternative. This review provides a brief account of the current knowledge, pra … amin.rostami@manchester.ac.uk Centre for Applied Pharmacokinetics Research (CAPKR), University of Manchester, Manchester, UK Certara, Blades Enterprise Centre, Sheffield, UK 2014-08-01 Title: Prediction of Intestinal First-Pass Drug Metabolism VOLUME: 8 ISSUE: 7 Author(s):Jiansong Yang, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker and Amin Rostami-Hodjegan Affiliation:Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU, United Kingdom. Keywords:First-pass metabolism, gut metabolism, CYP3A, P-glycoprotein, drug transport, well-stirred model Narciso Couto, Zubida M. Al-Majdoub, Brahim Achour, Phillip C. Wright, Amin Rostami-Hodjegan and Jill Barber Abstract ABSTRACT: There is an urgent need (recognized in FDA guidance, 2018) to optimize the dose of medicines given to patients for maximal drug efficacy and limited toxicity (precision dosing), which can be facilitated by quantitative systems pharmacology (QSP) models.

Most frequent co-Author Amin Rostami-Hodjegan, Professor of Systems Pharmacology, University of Manchester Amin is a Professor of Systems Pharmacology at the Centre for Applied Pharmacokinetic Research (CAPKR) in the School of Pharmacy and Pharmaceutical Sciences at the University of Manchester. He has an active program of training PhD students in Amin Rostami-Hodjegan talks with ScienceWatch.com and answers a few questions about this month's Fast Breaking Paper in the field of Pharmacology & Toxicology.: Article Title: Simulation and prediction of in vivo drug metabolism in human populations from in vitro data Research Explorer. The University of Manchester's research has real-world impact beyond academia.
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Erik Mosekilde · Biosimulation in Biomedical Research, Health Care

He has an active program of training PhD students in Amin Rostami-Hodjegan talks with ScienceWatch.com and answers a few questions about this month's Fast Breaking Paper in the field of Pharmacology & Toxicology. Article Title: Simulation and prediction of in vivo drug metabolism in human populations from in vitro data Amin Rostami-Hodjegan. University of Sheffield, Sheffield, UK See all articles by this author. Search Google Scholar for this author.